Basic Question - Trying to set up 'my Grid'

I am trying to set up my grid with Macros. I have gone through the stages in the manual and it seems to work but then the ‘button’ disappears from the grid. I feel like there should be a final ‘save’ stage after each button is set up but I can’t find anything. Starting to get frustrating so any tips gratefully received.

Ben - what does it mean that the button disappear from the grid - each change is saved on the fly so there is no need to have the global save button. Can you please explain your process?